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A total of three % of Energetic compound is excreted in urine as unchanged Energetic substance. Tapentadol is additionally metabolised to N-desmethyl tapentadol (thirteen %) by CYP2C9 and CYP2C19 and also to hydroxy tapentadol (two %) by CYP2D6, which can be further metabolised by conjugation. Thus, Lively material metabolism mediated by cytochrome

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